Overview
A high fever, a cough, red and watery eyes, and then a rash that starts on the face and works its way down the body over the following days. That is the shape measles usually takes, and it is one of the most contagious illnesses there is, far more so than most people realise.
Key Fact
Warning
AT A GLANCE
Disease Summary
Symptoms
Common Symptoms
Measles usually develops in a fairly predictable order, starting several days before the rash appears.
Fever
Cough and Runny Nose
Red, Watery Eyes
Tiny White Spots in the Mouth
Rash
Danger Signs
Seek emergency medical attention immediately if any of the following develop.
Difficulty Breathing
Unusual Drowsiness, Confusion, or Seizures
Signs of Dehydration
High Fever That Will Not Come Down
Diagnosis
Clinical Assessment
Blood Test for Measles Antibodies (IgM)
PCR Testing
Laboratory Tests
Measles IgM Antibody Test
Detects the immune system’s early response and confirms a current or recent measles infection.
Measles IgG Antibody Test
Helps confirm past infection or immunity, sometimes used alongside the IgM test.
RT-PCR Testing
Detects the virus’s genetic material directly, useful early in the illness or to confirm the specific measles strain during an outbreak.
Complete Blood Count (CBC)
Does not confirm measles on its own but can help assess overall health and rule out other causes of fever.
Laboratory Note
Laboratory confirmation matters most for outbreak tracking and for cases where the diagnosis is not clinically obvious. Treatment decisions are usually made on clinical grounds without waiting for results.
Treatment
Supportive Care
Rest, fluids, and fever management support recovery, since there is no specific antiviral medicine for measles.
Vitamin A Supplementation
Recommended by the WHO for children diagnosed with measles, particularly in areas where vitamin A deficiency is common. It can reduce the risk of severe complications and death, though it does not prevent measles and is not a substitute for vaccination.
Treatment Note
Antibiotics have no effect on the measles virus itself but may be prescribed to treat bacterial complications such as ear infections or pneumonia.
Prevention
Get the MMR vaccine
Two doses of the measles, mumps, and rubella (MMR) vaccine offer strong, long-lasting protection and are the most effective way to prevent measles.
Check vaccination status before travel
Travellers to areas with ongoing measles activity should confirm they are fully vaccinated at least two weeks before departure.
Avoid contact with infected individuals
Since measles spreads easily through the air, avoiding close contact with someone who has a suspected or confirmed case reduces the risk of transmission.
Support community vaccination coverage
High vaccination rates within a community protect those who cannot be vaccinated themselves, such as very young infants or people with weakened immune systems.
Prevention Note
Vitamin A supplementation does not prevent measles and is not a substitute for the MMR vaccine. Vaccination remains the only reliable way to prevent infection.
Risk Factors
Higher Risk of Severe Illness
These groups face a greater chance of severe illness or complications if infected.
- Children under 5
- Adults over 20
- Pregnant women
- People with weakened immune systems
Increased Chance of Infection
These groups have a higher chance of being exposed to the measles virus.
- Unvaccinated individuals of any age
- People living in or travelling to areas with active measles outbreaks
Exposure Factors
Conditions that increase the risk of exposure or worsen outcomes.
- Vitamin A deficiency, more common where access to a varied diet is limited
- Crowded living or gathering conditions
Risk Note
Because measles spreads so easily, even brief contact with an infected person in a shared space can be enough to catch it if you are not immune.
Complications
Pneumonia
The most common cause of death from measles in young children.
Encephalitis
Swelling of the brain that can cause seizures and lead to lasting disability, though it is uncommon.
Severe Diarrhoea and Dehydration
Can develop quickly, particularly in young children, and requires prompt fluid replacement.
Complication Note
Most children recover from measles without lasting effects, especially with prompt supportive care and vitamin A supplementation where appropriate. Complications are more likely in children under five, adults over twenty, and people with weakened immune systems.
When to Seek Medical Care
Difficulty Breathing
Rapid or laboured breathing needs urgent medical attention.
Unusual Drowsiness, Confusion, or Seizures
A change in alertness or new seizures require emergency care.
Signs of Dehydration
Little or no urination, sunken eyes, or extreme thirst should be assessed promptly.
Fever That Persists Beyond a Few Days
A fever that does not improve, or that returns after initially settling, should be reviewed by a healthcare provider.
Emergency Advice
Measles can be serious at any age but is especially risky for young children, pregnant women, and anyone with a weakened immune system. Do not wait to seek care if danger signs develop.
Prognosis
Good for Most People
Most people recover within two to three weeks with supportive care.
Complications Are More Likely in Certain Groups
Young children, adults over twenty, pregnant women, and people with weakened immune systems face a higher risk of severe illness.
A Rare Late Complication Can Occur Years Later
Subacute sclerosing panencephalitis (SSPE) is a very rare but fatal condition that can develop several years after a measles infection, most often in those infected before the age of two.
Prognosis Note
Measles remains one of the leading vaccine-preventable causes of death among young children worldwide, particularly where vaccination coverage is low. Vaccination has prevented millions of deaths globally.
Differential Diagnosis
Rubella
Rubella causes a similar rash but is generally much milder, with a shorter illness and fewer complications.
Malaria
In the days before the rash appears, measles can resemble malaria or other fever-causing illnesses common in the region, and should be considered and ruled out.
Roseola
Common in young children, roseola causes a high fever followed by a rash, but the rash typically appears as the fever breaks rather than days into the illness.
Clinical Note
The distinctive pattern of fever followed by Koplik spots and then a descending rash helps distinguish measles from other rash-causing illnesses, though laboratory confirmation is useful during outbreaks or uncertain cases.
References
World Health Organization (WHO)
World Health Organization fact sheet on measles transmission, symptoms, diagnosis, treatment, and prevention.
Centers for Disease Control and Prevention (CDC)
Clinical and public health guidance on measles causes, symptoms, and complications.
CDC Clinical Overview of Measles
Clinical guidance for healthcare providers on measles diagnosis, laboratory testing, and the role of vitamin A in management.